Wireless recording and autoencoder denoising of intestinal activity in freely moving rats
Conventional wired systems for recording intestinal motility using strain-gauge transducers physically limit animal movement and are not ideal for long-term studies. Here, we developed a wireless recording system that allows continuous monitoring of intestinal activity in freely moving rats. We also developed a denoising autoencoder that isolates intestinal motility signals from locomotor noise while maintaining a 10-s temporal resolution. The refined data revealed decreased intestinal motility while the rats were behaviorally active. This system has broad applications for in vivo physiological research.
Authors
- Yuji Ikegaya (ORCID: https://orcid.org/0000-0003-2260-8191)
- Nobuyoshi Matsumoto (ORCID: https://orcid.org/0000-0002-0426-9416)
- Yoshikazu Ishii (ORCID: https://orcid.org/0000-0002-1943-4648)
- Tetsuhiko Kashima (ORCID: https://orcid.org/0000-0002-1802-6482)
Institutions
- The University of Tokyo (JP)
- National Institute of Information and Communications Technology (JP)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.jphs.2025.03.005
- Citations
- 3
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- Japan Agency for Medical Research and Development
- Japan Science and Technology Corporation
- University of Tokyo
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology
- Exploratory Research for Advanced Technology