Spinal Phlegmon Secondary to Neisseria meningitidis Meningitis With Possible Herpes Simplex Virus 1 Co-infection in an Immunocompetent Pediatric Patient

Spinal phlegmon has rarely been reported in meningococcemia. Simultaneous polymicrobial infection has been occasionally reported as the etiology of meningitis. The development of a spinal phlegmon and optic neuritis complicated meningitis in a five-year-old male who presented with clinical sepsis and meningitis. <i>Neisseria meningitidis</i> (<i>N. meningitidis</i>) and herpes simplex virus 1 (HSV-1) were demonstrated in the cerebrospinal fluid. Investigation of potential immunocompromise revealed no identified deficit. Protracted antibiotics and antiviral therapy were completed with a favorable clinical outcome. This is potentially the first reported case of spinal phlegmon associated with meningococcal meningitis in an immunocompetent pediatric patient. It occurred in the clinical context of what appeared to be a simultaneous infection by <i>N. meningitidis</i> and HSV-1.

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Journal
Cureus
Published
2025-03-14
DOI
https://doi.org/10.7759/cureus.80585
Primary Topic
Bacterial Infections and Vaccines
Type
article
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0.00
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article

Spinal Phlegmon Secondary to Neisseria meningitidis Meningitis With Possible Herpes Simplex Virus 1 Co-infection in an Immunocompetent Pediatric Patient

Peter Paul Lim, Eric R. Hines, Mark K Huntington, Mark Keith et al.
Cureus
Bacterial Infections and Vaccines
article

Spinal Phlegmon Secondary to Neisseria meningitidis Meningitis With Possible Herpes Simplex Virus 1 Co-infection in an Immunocompetent Pediatric Patient

Peter Paul Lim, Eric R. Hines, Mark K Huntington, Mark Keith, Kayla Morisette
article en

Abstract

Spinal phlegmon has rarely been reported in meningococcemia. Simultaneous polymicrobial infection has been occasionally reported as the etiology of meningitis. The development of a spinal phlegmon and optic neuritis complicated meningitis in a five-year-old male who presented with clinical sepsis and meningitis. <i>Neisseria meningitidis</i> (<i>N. meningitidis</i>) and herpes simplex virus 1 (HSV-1) were demonstrated in the cerebrospinal fluid. Investigation of potential immunocompromise revealed no identified deficit. Protracted antibiotics and antiviral therapy were completed with a favorable clinical outcome. This is potentially the first reported case of spinal phlegmon associated with meningococcal meningitis in an immunocompetent pediatric patient. It occurred in the clinical context of what appeared to be a simultaneous infection by <i>N. meningitidis</i> and HSV-1.

CureusVol. 17(3)
University of South Dakota (US), University of Sioux Falls (US), Avera McKennan Hospital & University Health Center (US)
Good health and well-being
Openalex Percentile: Top 95%
Bacterial Infections and Vaccines
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Spinal Phlegmon Secondary to Neisseria meningitidis Meningitis With Possible Herpes Simplex Virus 1 Co-infection in an Immunocompetent Pediatric Patient — Peter Paul Lim, Eric R. Hines, et al. · Cureus (2025) | TGRS Research Map | TGRS