Jiangniaosuan formula inhibits hyperuricemia-induced apoptosis of renal tubular epithelial cells via ROS/HIF-1α/EZH2 pathway: A network pharmacology analysis and experimental validation
JNSF may attenuate HUA-induced renal injury by inhibiting apoptosis through the downregulation of ROS/HIF-1α/EZH2 pathway.
Authors
- Jiabao Zhou
- Zhiyuan Wu (ORCID: https://orcid.org/0000-0002-0466-5996)
- Xuming Zhang (ORCID: https://orcid.org/0000-0002-5331-8675)
- Jiandong Gao
- Chuanxu Wang (ORCID: https://orcid.org/0000-0002-3004-0738)
- Feng Yang
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Bioorganic Chemistry
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.bioorg.2025.108363
- Citations
- 3
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 4.29
Funders
- National Natural Science Foundation of China