Gut microbiota community and metabolic profiles in direct total cavopulmonary connection and Fontan circulation: a cross-sectional study in the single center
The dTCPC procedure demonstrated similar gut microbiota composition and metabolic profiles to the traditional ECC procedure in Fontan patients. Notably, the increased abundance of <i>Fusobacterium</i>, reduced microbial biodiversity, and altered metabolic profiles of amino acids and unsaturated fatty acids in the alimentary canal may serve as distinctive characteristics of patients who have undergone Fontan circulation. These findings provide valuable insights into the long-term physiological consequences of Fontan procedure and may inform future clinical management strategies.
Authors
- Yuqiang Fang (ORCID: https://orcid.org/0000-0001-9096-2286)
- Linjiang Han
- Yinru He (ORCID: https://orcid.org/0000-0003-3615-5939)
- Haiyun Yuan (ORCID: https://orcid.org/0000-0002-8884-4202)
- Xiaobing Liu (ORCID: https://orcid.org/0000-0002-3754-0786)
- Jianrui Ma (ORCID: https://orcid.org/0000-0002-9501-2244)
- Shusheng Wen
- Kaiyu Wang (ORCID: https://orcid.org/0000-0002-9300-7265)
- Jian Zhuang
Institutions
- South China Sea Institute Of Oceanology (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1539046
- Citations
- 2
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province