Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength
DMI of the human abdomen is feasible using a clinical magnetic resonance imaging system and the signal changes measured in the kidney and liver can serve as a reference for future clinical studies. The 2 H-glucose dose can be reduced from 0.75 to 0.50 g/kg to minimize gastric signal without substantially affecting the reliability of organ quantification. The increase in 2 H-lipid+lactate or 2 H-water signal over time could serve as direct and indirect measures of metabolism, respectively.
Authors
- Elizabeth Latimer
- Rolf F. Schulte (ORCID: https://orcid.org/0000-0002-1334-1264)
- Mary A. McLean (ORCID: https://orcid.org/0000-0002-3752-0179)
- Ines Horvat‐Menih (ORCID: https://orcid.org/0000-0002-1373-6944)
- Ferdia A. Gallagher (ORCID: https://orcid.org/0000-0003-4784-5230)
- Marta Wylot
- Jonathan R. Birchall (ORCID: https://orcid.org/0000-0003-3920-4038)
- Ashley Grimmer (ORCID: https://orcid.org/0000-0001-6013-5271)
- Pascal Wodtke (ORCID: https://orcid.org/0000-0002-6109-4261)
- Maria Jesus Zamora Morales
Institutions
- MRC Cancer Unit (GB)
- Ferioli & Gianotti (Italy) (IT)
- Faculty of 1000 (United States) (US)
Publication Details
- Journal
- Investigative Radiology
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1097/rli.0000000000001170
- Citations
- 6
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.16