Black phosphorus enabled non-invasive protein detection with electromagnetic induction well terahertz biosensor chips
Terahertz biosensors are employed to detect proteins in cancer cells to facilitate early diagnosis and monitoring of cancer treatments. By optimizing the design and functionality of black phosphorus-based sensors, it is possible to enhance their sensitivity and specificity for specific cancer biomarkers, leading to more accurate diagnostic outcomes. The application of the externally applied magnetic field and the 455 nm continuous-wave laser further augments the sensitivity of cellular responses to THz waves, with magnetic influences typically surpassing those of light fields by 10%-80%. Our results examine the photonic properties of black phosphorus, improve its interaction with terahertz waves, and create prototypes that can selectively identify proteins associated with cancer cells. Additionally, the stability and reproducibility of these sensors have been greatly improved, boosting their potential for widespread use in clinical environments.
Authors
- Min Zhang (ORCID: https://orcid.org/0000-0002-0910-2172)
- Bingyuan Zhang (ORCID: https://orcid.org/0000-0001-8989-1791)
- Qi Song (ORCID: https://orcid.org/0000-0002-1167-871X)
- Peng Jing (ORCID: https://orcid.org/0000-0003-2058-2995)
- Wenhao Xu (ORCID: https://orcid.org/0000-0001-9250-7607)
- Xiaoguang Xu (ORCID: https://orcid.org/0000-0003-4568-1623)
- Xin Chen (ORCID: https://orcid.org/0000-0003-2706-5069)
- Hongzhuan Xuan (ORCID: https://orcid.org/0000-0002-7823-1488)
- Xin Hu (ORCID: https://orcid.org/0000-0002-1975-2910)
- Xinhai Zhao
Institutions
- Nuance Communications (Austria) (AT)
- Shenzhen University (CN)
- Liaocheng University (CN)
- Shenzhen Academy of Inspection and Quarantine (CN)
- Southerners on New Ground (US)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1364/boe.554409
- Citations
- 4
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China