Nonuremic, Warfarin-Associated Calciphylaxis

ABSTRACT Calciphylaxis is a rare condition of cutaneous ischemia resulting from calcium deposition into dermal and subcutaneous blood vessels, followed by thrombosis. It most often occurs in the setting of end-stage renal disease (uremic calciphylaxis) but can also occur in the absence of renal disease (nonuremic calciphylaxis) and may be associated with a variety of comorbidities or medication triggers. This article details a case of nonuremic, warfarin-associated calciphylaxis in a 64-year-old female with Factor V Leiden deficiency and provides a review of calciphylaxis clinical presentation, pathophysiology, risk factors, diagnosis, mimickers, and management.