Global deletion of the LXR-regulated gene EEPD1 reveals macrophage-specific changes in lipid metabolism and cholesterol efflux
Loss of Eepd1 results in an altered lipidomic landscape and reduced LXR-stimulated cholesterol efflux in BMDM, but myeloid-specific loss of Eepd1 does not influence atherogenesis in mice.
Authors
- Aldo Jongejan (ORCID: https://orcid.org/0000-0002-8948-2549)
- Jeroen F. J. Bogie (ORCID: https://orcid.org/0000-0002-0016-1926)
- Jenina Kingma (ORCID: https://orcid.org/0000-0003-2822-5415)
- Roelof Ottenhoff (ORCID: https://orcid.org/0000-0003-3023-1128)
- Menno Hoekstra (ORCID: https://orcid.org/0000-0001-7463-2893)
- Noam Zelcer (ORCID: https://orcid.org/0000-0001-6935-7532)
- Melanie Loix (ORCID: https://orcid.org/0000-0002-4107-6816)
- Suzanne A.E. van Wouw (ORCID: https://orcid.org/0000-0003-2508-2295)
Institutions
- Leiden University (NL)
- Amsterdam Neuroscience (NL)
- Centre for Human Drug Research (NL)
- Amsterdam University Medical Centers (NL)
- Hasselt University (BE)
- University of Amsterdam (NL)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119163
- Citations
- 4
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Hartstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek