Transcriptomic and proteo-metabolic determinants of the grading system in clear cell renal cell carcinoma
ccRCC is characterized by a particular grade-dependent metabolic reprogramming. Metabolic pathways and associated molecular alterations are grade-specific and could represent potential therapeutic targets, especially in HG tumors. sRCC subclassification based on the abundance of sarcomatoid components into HS vs. LS tumors have prognostic value.
Authors
- Cristina Bianchi (ORCID: https://orcid.org/0000-0001-6305-1487)
- Francesco M. Lasorsa (ORCID: https://orcid.org/0000-0001-8418-5222)
- Giuseppe Lucarelli (ORCID: https://orcid.org/0000-0001-7807-1229)
- Mariella Errede (ORCID: https://orcid.org/0000-0002-8163-2338)
- P. Ditonno
- Michele Battaglia (ORCID: https://orcid.org/0000-0002-2453-2349)
- Marco Spilotros (ORCID: https://orcid.org/0000-0003-1237-3018)
- Martina Milella
- Monica Rutigliano
- Giuseppe Ingravallo (ORCID: https://orcid.org/0000-0002-4792-3545)
- Antonio d’Amati (ORCID: https://orcid.org/0000-0002-4810-1201)
- Mariella Silecchia
Institutions
- University of Bari Aldo Moro (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1016/j.urolonc.2025.02.016
- Citations
- 22
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 33.40