Photoredox Site-Selective C(sp<sup>3</sup>)–H Alkylation of 1-(<i>o</i>-Iodoaryl)-alkan-1-ones with Activated Alkenes Enabled by Hydrogen Atom Transfer
A visible-light-mediated photoredox catalysis for β-C(sp<sup>3</sup>)-H alkylation of 1-(<i>o</i>-iodoaryl)alkan-1-ones with alkenes via 1,5-hydrogen atom transfer and alkene alkylarylation to produce diverse β-alkyl arylalkanones containing a quaternary carbon center is presented. This method is applicable to a wide range of 1-(<i>o</i>-iodoaryl)alkan-1-ones and activated alkenes. Mechanistic studies suggest that the reaction involves a radical process.
Authors
- Zitong Lu
- Shuang Wu
- Jin‐Heng Li (ORCID: https://orcid.org/0000-0001-7215-7152)
- Liang Zeng (ORCID: https://orcid.org/0009-0000-3012-4651)
- Mingzhu Zhang (ORCID: https://orcid.org/0000-0002-6944-2558)
- Ming Hu (ORCID: https://orcid.org/0000-0002-3053-0905)
Institutions
- Qingdao University of Science and Technology (CN)
- State Key Laboratory of Chemical Engineering (CN)
- State Key Laboratory of Applied Organic Chemistry
- Henan Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c00597
- Citations
- 7
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- Henan Normal University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Taishan Scholar Project of Shandong Province
- Jiangxi Provincial Department of Science and Technology