In vitro study of a siRNA delivery liposome constructed with an ionizable cationic lipid.
LKA, an ionizable cationic lipid, can form LKA-LP liposomes for siRNA delivery. The system successfully achieved gene silencing at the cellular level, showing specific cytotoxicity to HeLa cells, providing a solid foundation for developing nucleic acid therapeutics using LKA-LP as a nucleic acid delivery vehicle.
Authors
- Dun Hu
- Junna Zou
- Yan Wang (ORCID: https://orcid.org/0000-0002-2277-4002)
- Shan Wang (ORCID: https://orcid.org/0000-0002-1402-1051)
- Shengdan Nie (ORCID: https://orcid.org/0000-0002-2901-3396)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2024.230247
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.23