ZNF667 alleviates the inflammatory damage in intervertebral disc degeneration via inhibiting NF-κB signaling pathway.
ZNF667 can alleviate nucleus pulposus cell apoptosis and inflammatory responses by inhibiting the NF-κB signaling pathway, thereby exerting a protective effect on intervertebral discs. This finding not only provides new insights into the pathogenesis of IDD but also suggests a potential therapeutic target for its treatment.
Authors
- Lebin Guo
- Chenjun Tian
- Bo‐Wen Zheng (ORCID: https://orcid.org/0000-0002-9308-3794)
- Fusheng Liu
- Yan Yang (ORCID: https://orcid.org/0000-0003-4862-064X)
- Hua Zhong (ORCID: https://orcid.org/0000-0002-9358-1582)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2024.240122
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00