Sequential Proteomic Analysis Reveals the Key <scp>APOE4</scp>‐Induced Pathological and Molecular Features at the Presymptomatic Stage in Alzheimer's Disease Mice
Our findings indicate that APOE4 accelerates AD pathologies at the presymptomatic stage by exacerbating Aβ deposition, neuroinflammation, and synaptic degeneration. The study highlights mitochondrial dysfunction as a critical mediator of APOE4-induced AD progression, providing potential targets for early intervention.
Authors
- Jun Hu (ORCID: https://orcid.org/0000-0001-9468-9854)
- Linhui Qiu
- Junlei Chang (ORCID: https://orcid.org/0000-0002-0319-9022)
- Kaihua Lin
- Pengju Wei
- Xuhui Chen (ORCID: https://orcid.org/0000-0001-6405-6810)
- Cheng Fang (ORCID: https://orcid.org/0009-0000-9684-4870)
Institutions
- Chinese Academy of Sciences (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70306
- Citations
- 8
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- National Natural Science Foundation of China
- CAS-Croucher Funding Scheme for Joint Laboratories
- National Key Research and Development Program of China