PD-L1+ CD49f+ CD133+ Circulating tumor cells predict outcome of patients with vulvar or cervical cancer after radio- and chemoradiotherapy
Our study unravels individual therapy-induced changes in CTC phenotypic characteristics and occurrence in the patients' blood and their association with cancer relapse. Our results may help to explain differences in the individual courses of disease of patients with vulvar and cervical cancer and suggest PD-L1, CD49f and CD133 as targets for immunotherapy in vulvar and cervical cancer.
Authors
- Russalina Stroeder (ORCID: https://orcid.org/0000-0001-8320-4823)
- Martina Sester (ORCID: https://orcid.org/0000-0001-5482-0002)
- Barbara Walch‐Rückheim (ORCID: https://orcid.org/0000-0003-3355-8978)
- Gregor Olmes
- Laura Theobald
- Maike Pohlers
- Patrick Melchior
- Tanja Tänzer
- Moritz Schäfer
- István Molnár
- Erich Solomayer
- Selina Gies
Institutions
- University of Augsburg (DE)
- Saarland University (DE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12967-025-06277-w
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Wilhelm Sander-Stiftung
- Universität des Saarlandes