Iguratimod improves bleomycin-induced pulmonary inflammation and fibrosis by regulating macrophage polarization through inhibiting the TLR4/NF-κB pathway
In summary, IGU inhibits the activation of macrophages and M1 polarization through inhibiting the TLR4/NF-κB pathway, thereby improving BLM-induced pulmonary inflammation and fibrosis in mice. It is suggested that IGU may be a new therapeutic option for interstitial pulmonary fibrosis.
Authors
- Huan Xu (ORCID: https://orcid.org/0000-0001-8445-9166)
- Koval' Ma
- Tingting Zhuang
- Ling Lin (ORCID: https://orcid.org/0000-0002-4612-2420)
- Z. Ma (ORCID: https://orcid.org/0009-0007-2543-0735)
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1558903
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04