A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery
This dual-reporter system enables complementary monitoring of LDLR dynamics, providing enhanced sensitivity, accuracy, and versatility for studying LDLR regulation and function, as well as facilitating drug discovery targeting hyperlipidemia and cardiovascular diseases.
Authors
- Shengtian Zhao (ORCID: https://orcid.org/0000-0003-4458-6202)
- Na Yang (ORCID: https://orcid.org/0000-0002-2888-8588)
- Baozhen Fan
- Ke Feng (ORCID: https://orcid.org/0000-0003-0430-1866)
- Jimmy C. Yu (ORCID: https://orcid.org/0000-0001-9886-3725)
- Peng Jiao
- Qianfeng Jia
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fmolb.2025.1552085
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00