Transcriptomic and proteomic analyses of sclera in lens-induced myopic guinea pigs
Axial elongation-related remodeling of scleral collagen is closely linked to circadian rhythm and hypoxia pathways, with RORα, RORβ, melatonin receptors, and HIF-1α identified as potential key regulators. Additionally, scleral fiber size decreases progressively with scleral remodeling in myopia development.
Authors
- Ruiheng Zhang (ORCID: https://orcid.org/0000-0002-5460-7196)
- Heyan Li (ORCID: https://orcid.org/0009-0002-6558-4724)
- Wen‐Da Zhou
- Dong Li (ORCID: https://orcid.org/0000-0002-1084-4624)
- Yi-Tong Li
- Xu‐Han Shi
- Haotian Wu (ORCID: https://orcid.org/0000-0002-6271-0249)
- Chuyao Yu
- Jost Bruno Jonas (ORCID: https://orcid.org/0000-0003-2972-5227)
- Wenbin Wei (ORCID: https://orcid.org/0000-0003-2386-0989)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Institut Français (FR)
- Singapore National Eye Center (SG)
- Singapore Eye Research Institute (SG)
- Fondation de Rothschild (FR)
- Ministry of Industry and Information Technology (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12864-025-11422-2
- Citations
- 6
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 11.27
Funders
- National Natural Science Foundation of China
- Capital Health Research and Development of Special Fund