Inflammatory Responses of High Mobility Group Protein B1 in Disease: Current Trends, novel Insights, and challengesResearch Article

HMGB1, a key member of the HMG protein family, stabilizes nucleosomes and mediates infection, injury, and late inflammatory responses. Its related research is crucial in critical care medicine, cancer, and neurological diseases, yet current reports inadequately present its status. This review makes a comprehensive bibliometric analysis of the past hmgb1 research, and makes a graphical analysis of the trends and hotspots of HMGB1-related research. From 1976 to 2024, a total of 5992 articles were included, and the number of published papers and citations showed an increasing trend. China and the United States are leading contributors in this field, with the University of Pittsburgh being the most prominent research institution. Among the authors, Billiar, Timothy R. is the most prolific author, while Yang, H. ranks first in co-citation frequency. Inspection of the literature and keywords reveals that disease and its clinical diagnosis and treatment, cell death, mechanism, and molecular pattern are popular research topics. About disease frontiers, critical care medicine (sepsis, endotoxemia, severe viral hemorrhagic fever, multiple organ failure) is the earliest identified and very popular direction of HMGB1, and neurological diseases-related research are at the forefront of the field. In summary, this study employs bibliometrics to identify, visualize, and discuss trends and hotspots in HMGB1 research. Through comprehensive analysis of extensive literature, the aim is to clarify the current research status of HMGB1-related diseases, understand major trends, find potential collaborators, and discover promising and innovative research directions.