Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study
LDL-C reduction estimated by SNPs in LDL-C lowering drug target genes significantly reduced the risk of CAD. We found the potential of using of proxy research design for clinical trials using LDL-C lowering drugs.
Authors
- Jong Won Shin (ORCID: https://orcid.org/0009-0003-8587-1445)
- Mikyung Ryu (ORCID: https://orcid.org/0000-0002-9915-3175)
- Tae-Jin Song (ORCID: https://orcid.org/0000-0002-6356-0676)
- Yongho Jee
Institutions
- Ulsan College (KR)
- Ewha Womans University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Ajou University (KR)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12944-025-02502-z
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Research Foundation of Korea