Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways
PM alleviates CI by reducing inflammation and oxidative stress, protecting the blood-brain barrier (BBB) and intestinal barrier, inhibiting the NF-κB pathway, activating the cAMP pathway, and regulating gut microbiota.
Authors
- Hui Ao (ORCID: https://orcid.org/0000-0001-5763-6147)
- Cheng Peng (ORCID: https://orcid.org/0009-0003-4504-7750)
- Yingqi Meng
- Fei‐Yan Deng (ORCID: https://orcid.org/0000-0001-7553-5358)
- Wen Li (ORCID: https://orcid.org/0009-0008-3930-6302)
- Si Liu (ORCID: https://orcid.org/0000-0003-0171-9124)
- Yang Yang (ORCID: https://orcid.org/0000-0001-7432-4735)
- Ping Yan (ORCID: https://orcid.org/0000-0001-7523-9460)
- Huang Li-hua (ORCID: https://orcid.org/0009-0000-3872-6438)
- Dan Yang
- Qiuping Chen
Institutions
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Southwestern Institute of Physics (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s506545
- Citations
- 4
- Primary Topic
- Magnolia and Illicium research
- Type
- article
- Field-Weighted Citation Impact
- 4.10