Effect of narcotic analgesics on postoperative vegetative tone in children

Objective. To analyze the effect on morphine hydrochloride and dipidolor on autonomic nervous system in postoperative period in children. Material and methods. Narcotic analgesics were used in 82 children aged 4—14 years after surgery on abdominal, retroperitoneal and chest organs, as well as musculoskeletal system. Dipidolor was used in 52 patients at a dose of 0.3 mg / kg, morphine hydrochloride — in 30 patients at a dose of 0.3 mg/kg intramuscularly. To analyze stress of cardiovascular regulatory mechanisms following postoperative pain syndrome, we performed cardiointervalography with subsequent analysis of heart function. Behavioral indicators and VAS scores of pain intensity were recorded. Blood gases and acid-base balance were estimated using the AVL-2 analyzer (Japan). We controlled heart rate, blood pressure and respiratory rate throughout the follow-up period. Results. Postoperative pain relief with narcotic analgesics significantly decreased sympathetic effects in children that confirmed adequate pain relief. In turn, vegetative stabilization improved hemodynamics, respiration and metabolism in postoperative period.