Age dynamics of biochemical blood parameters of laboratory mice of the ICR line, who participated as a control group in studies on the influence of environmental factors

Annotation. The aim of the study was to trace the age dynamics of indicators (30-60-90 days) in laboratory mice of the ICR line (weighing 45-50 g, sexually mature age – 6 months), contained in standard comfortable conditions and not subjected to stressful effects of environmental factors, to establish reference (reference) values of biochemical blood parameters. Material and methods: In determining the reference (reference) values of biochemical blood parameters in outbred (nonlinear) laboratory mice ICR (CD-1), methods of theoretical and practical research were used: clinical, biochemical research methods, as well as formalization, generalization, comparison and system analysis. The object of the study was laboratory mice ICR (CD-1), in the number of 130 individuals of different sexes, mature age 5-5.5 months, weighing 45-50 g., in which hematological and plasma biochemical reference values were determined in 90-day dynamics, to establish reference values of blood parameters in studies of physiological and pathological reactions potentiated by the influence of physical and chemical factors of the production environment under model conditions. The results and their discussion. The data of the obtained reference values of biochemical blood parameters in 6-month-old outbred (nonlinear) laboratory mice ICR (CD-1) in age dynamics on the 30th, 60th and 90th days of the experiment indicate the variability of the biochemical composition of the blood, and the aging processes starting from the age of 8 months (based on changes in biochemical parameters blood and the results of our own histological examination of mouse tissues on the 90th day of observation. Conclusion. The data obtained during a 90-day observation of the age dynamics (6, 7, 8, 9 months of mouse life) of biochemical blood parameters in laboratory mice of the "ICR" line, when compared with significant variability in the literature data, allow us to recommend their use as reference values. The conducted research will allow a deeper understanding of the processes leading to a change in biological age and the development of premature aging by analyzing the obtained reference values of the biochemical composition of blood and other indicators affecting health and life expectancy.