Design of a Highly Active Peptide Inhibitor of Farnesyltransferase and Its Protective Effect Against Acute Liver Failure
Collectively, these findings demonstrate that PD081376(d2,d3,d5) could alleviate LPS/D-GaIN or TAA-induced ALF by regulating apoptosis, pyroptosis, and necrotizing apoptosis, which might provide a new therapeutic strategy and scalability challenge for ALF.
Authors
- Chen-Qian Ying
- Yongzhi Tang
- Tao‐Hsin Tung (ORCID: https://orcid.org/0000-0003-2097-8375)
- Huazhong Chen (ORCID: https://orcid.org/0000-0003-0516-260X)
- Anne Li (ORCID: https://orcid.org/0000-0001-5449-7022)
- Hui Qu (ORCID: https://orcid.org/0000-0003-0061-913X)
- Hui Shao (ORCID: https://orcid.org/0000-0003-0855-0704)
- Chun-Lian Huang (ORCID: https://orcid.org/0009-0007-6748-2867)
- Jiansheng Zhu (ORCID: https://orcid.org/0000-0002-4961-7437)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s505541
- Citations
- 2
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 2.24