Global research status and hotspots of squamous cell carcinoma endothelial cells in the last 20 years: A bibliometric analysisResearch Article

Objective: The aim is to analyze the current research status and hotspots of squamous cell carcinoma endothelial cells and to provide a reference for the following fundamental research and clinical treatment. Methods: The Web of Science Core Collection (WOSCC) database was searched for literature on squamous cell carcinoma endothelial cells from January 1, 2004, to December 31, 2023. The results were analyzed for research trends, authors, countries, research institutions, and keywords using CiteSpace, VOSviewer, and the bibliometrixc data package in R language. Results: 3217 articles were included in the analysis, and the number of articles published in the past five years is relatively stable. The number of publications from 89 countries and 3,163 institutions has been relatively stable in the past five years, of which 800 are from China, 195 are from the University of Texas System, which is higher than that of other countries and institutions, and there is a big difference in the number of publications between countries and institutions. Prof. Marioni Gino has published 16 relevant papers, and 713 citations have been given to Forkman J, so there is more frequent cooperation between scholars. There are more frequent collaborations among scholars. Eight hundred sixty-eight journals published relevant papers, with Oral Oncology having the highest number of articles and Cancer Research having the highest number of citations. The most cited reference is “Hallmarks of cancer: the next generation,” DOI:10.1016/j.cell.2011.02.013 (intensity 21.75). In the last five years, keywords with high intensity are migration, tumor microenvironment, open-label, epithelial-mesenchymal transition, t cells, esophageal squamous cell carcinoma, and recurrent. Conclusion: The development of squamous cell carcinoma endothelial cell research is uneven among different countries, institutions, and authors, and the journal Oral Oncology publishes the most relevant papers, with current research hotspots including metastasis, recurrence, tumor microenvironment, epithelial-mesenchymal transition, and open labelling.