The investigation of molecular epidemiological characteristics and resistance mechanism of tigecycline resistant Klebsiella pneumoniae from a large teaching hospital in southwest China, Chongqing
The efflux pump <i>acrB</i> and <i>tet(A)</i> mutations are the primary mechanisms of resistance to <i>tigecycline-resistant Klebsiella pneumoniae</i> at our hospital. The <i>ramR</i> mutation can mediate efflux pump activity of <i>acrB</i> by up-regulating <i>ramA</i> overexpression.
Authors
- Yuanyuan Song (ORCID: https://orcid.org/0000-0002-5295-803X)
- Tingting Si (ORCID: https://orcid.org/0000-0002-9047-7616)
- Peiwen Xia
- Yun Xia (ORCID: https://orcid.org/0000-0003-0199-1531)
- Shiyu Tang (ORCID: https://orcid.org/0000-0001-6503-5878)
- Yuqiong Li (ORCID: https://orcid.org/0000-0001-5781-3537)
- Qi Han (ORCID: https://orcid.org/0000-0002-2140-4536)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fcimb.2025.1540967
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59