Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge
The combination of azithromycin with moderate cyclosporin concentrations (200 ng/ml) provides optimal immunomodulatory effects while maintaining cell viability. Higher cyclosporin doses (1,000 ng/ml) showed increased cytotoxicity despite enhanced immunomodulation.
Authors
- Omar Omar (ORCID: https://orcid.org/0000-0002-2610-1294)
- Norah Alotaibi (ORCID: https://orcid.org/0000-0001-6450-8776)
- Nada Alzahrani
- Faisal E. Aljofi (ORCID: https://orcid.org/0000-0002-1652-5325)
- Marwa Madi (ORCID: https://orcid.org/0000-0002-3014-0405)
- Aminah Alesawy (ORCID: https://orcid.org/0000-0001-9969-8274)
- Nada Aldossary
- Marwa Alalshaikh
Institutions
- King Fahd Hospital of the University (SA)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- Frontiers in Oral Health
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/froh.2025.1544821
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 0.00