Unraveling the spatial and signaling dynamics and splicing kinetics of immune infiltration in osteoarthritis synovium
This study delineates the spatial and transcriptional landscape of OA synovium, linking immune cell dynamics to localized inflammation. The identification of OLR1 and CD69 as spatial homeostasis drivers, alongside dysregulated signaling networks, offers novel therapeutic targets. These findings advance strategies to modulate immune infiltration and restore synovial homeostasis in OA.
Authors
- Zihang Zeng (ORCID: https://orcid.org/0000-0003-1900-8478)
- Tuo Wang (ORCID: https://orcid.org/0000-0002-9862-5038)
- Wuxun Peng (ORCID: https://orcid.org/0000-0001-9468-2580)
- Zhihong Xie (ORCID: https://orcid.org/0000-0002-4099-7744)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-2868-8957)
- Fei Zhang (ORCID: https://orcid.org/0000-0003-2354-7175)
- Chuan Wang (ORCID: https://orcid.org/0000-0003-3079-8431)
- Wentao Dong (ORCID: https://orcid.org/0000-0003-1656-1665)
Institutions
- Guiyang Medical University (CN)
- Sun Yat-sen University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1521038
- Citations
- 12
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 20.02