Expression of Tim-3 on neutrophils as a novel indicator to assess disease activity and severity in ankylosing spondylitis
Elevated Tim-3 expression on neutrophils correlates with increased inflammatory markers and AS activity. Treatment lowered Tim-3 MFI, suggesting its potential as an indicator for assessing AS disease activity and severity and as a feedback mechanism to reduce tissue damage from inflammation.
Authors
- Shaoling Zheng
- Shuyang Chen (ORCID: https://orcid.org/0000-0002-4760-4106)
- Xuechan Huang (ORCID: https://orcid.org/0000-0003-4961-6407)
- Weiming Deng (ORCID: https://orcid.org/0000-0002-6566-5308)
- Ruiqi Zhu
- Li T (ORCID: https://orcid.org/0000-0001-6438-2691)
- Chun Zheng
- Junming Chen (ORCID: https://orcid.org/0000-0002-9013-3047)
- Yuebing He
- Zhixiang Huang (ORCID: https://orcid.org/0000-0003-0282-8859)
- Guanqun Yi (ORCID: https://orcid.org/0000-0001-6031-3242)
- Yunqing Wang (ORCID: https://orcid.org/0000-0002-2164-0766)
Institutions
- Jinan University (CN)
- The First People's Hospital of Zhaoqing (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fmed.2025.1530077
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00