Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule
FTO promoted FLS apoptosis escape and RA progression by activating the NF-κB pathway through the m6A-dependent ENST00000619282/YTHDF1 axis. XFC inhibited this pathway by modulating FTO-mediated m6A modification, providing a novel RNA epigenetic regulatory strategy for RA treatment.
Authors
- Jian Liu (ORCID: https://orcid.org/0000-0001-7352-6757)
- Fanfan Wang (ORCID: https://orcid.org/0000-0002-1824-9213)
- Mingyu He (ORCID: https://orcid.org/0000-0002-7047-8910)
- Yue Sun (ORCID: https://orcid.org/0000-0001-7903-3638)
- Yanyan Fang (ORCID: https://orcid.org/0000-0001-8754-7786)
- Jianting Wen (ORCID: https://orcid.org/0000-0003-2757-8462)
- Ling Xin (ORCID: https://orcid.org/0000-0001-9986-4551)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1556764
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64