A novel tertiary lymphoid structure-associated signature accurately predicts patient prognosis and facilitates the selection of personalized treatment strategies for HNSCC
Our findings suggest that the TLS-related features of HNSCC patients hold promise as predictive indicators for immunotherapy efficacy and may offer novel insights for tailoring personalized treatment strategies in clinical practice.
Authors
- Gaoge Peng (ORCID: https://orcid.org/0000-0002-0162-6481)
- Jingang Xiao (ORCID: https://orcid.org/0000-0003-1300-7191)
- Lu Zeng
- Guobin Song
- Shixi Chen (ORCID: https://orcid.org/0000-0001-7282-0495)
- Yamin Yuan (ORCID: https://orcid.org/0000-0001-9222-5992)
- Timothy L. Chen
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-6351-8689)
- Tao Zhong (ORCID: https://orcid.org/0000-0003-1210-9268)
- Ziyue Luo (ORCID: https://orcid.org/0009-0006-0108-9088)
- Jinhao Zhang (ORCID: https://orcid.org/0009-0001-3898-4901)
- Lin Liu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Southwest Medical University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1551844
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.75