Study on the efficacy of IFN-γ- and sPD-1-overexpressing BMSCs in enhancing immune effects for the treatment of lung adenocarcinoma
IFN-γ- and sPD-1-overexpressing BMSCs effectively inhibit lung adenocarcinoma cell growth and tumor progression. The primary mechanisms include suppression of cancer cell growth, migration, and invasion; promotion of apoptosis and senescence in cancer cells; modulation of Treg cells; and inhibition of the PI3K/AKT signaling pathway and PD-1/PD-L1 pathways.
Authors
- Xingmin Wei (ORCID: https://orcid.org/0000-0002-5119-4998)
- Guisen Zheng
- Zhen Lv
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Y. W. Wang (ORCID: https://orcid.org/0009-0009-6149-8707)
- Jin Ma (ORCID: https://orcid.org/0000-0002-5417-0246)
- Yahui Xie
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1554467
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China