Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell–specific biomarker in women with unexplained infertility and diminished ovarian reserve
The current study presents that although the serum and follicular fluid INSL3 levels are significantly lower in women with DOR, the narrow margin between the DOR and control groups indicates that INSL3measurement may be insufficient on its own to be of diagnostic value for DOR. Further research with larger sample sizes is needed to validate these findings and explore the role of INSL3 in ovarian aging and infertility treatment.
Authors
- Elif Çiğdem Keleş (ORCID: https://orcid.org/0000-0002-2479-1236)
- Pınar Özcan (ORCID: https://orcid.org/0000-0002-0306-6422)
- Özlem Dural (ORCID: https://orcid.org/0000-0001-7475-9982)
- Ferhat Sezer
- Ahmet Altun (ORCID: https://orcid.org/0000-0003-2056-8683)
- Ertan Sarıdoğan (ORCID: https://orcid.org/0000-0001-9736-4107)
- Hikmet Tunç Timur (ORCID: https://orcid.org/0000-0002-1250-8579)
- C. Yıldız (ORCID: https://orcid.org/0000-0003-2047-7271)
- Havva Sevde Taha
Institutions
- Yeditepe University (TR)
- Dokuz Eylül University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Biruni University (TR)
- Sivas State Hospital (TR)
- University College London (GB)
- Istanbul University (TR)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12958-025-01367-2
- Citations
- 4
- Primary Topic
- Pregnancy-related medical research
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Bezmialem Vakıf Üniversitesi