DYRK1A roles in human neural progenitors
Together, the DYRK1A interactome in hNSCs and the gene expression changes induced by its depletion highlight the significant role of DYRK1A in regulating hNSC proliferation. Although the effects on various growth signaling pathways may appear contradictory, the overall impact is a marked reduction in hNSC proliferation. This research underscores the pivotal role of DYRK1A in neurodevelopment and identifies, among DYRK1A's protein partners and differentially expressed genes, potential novel candidate genes for NDDs and promising therapeutic targets for DYRK1A syndrome.
Authors
- Nathalie Drouot
- Alexandra Benchoua (ORCID: https://orcid.org/0000-0002-9980-6471)
- Irene Zapata-Bodalo
- Amélie Piton (ORCID: https://orcid.org/0000-0003-0408-7468)
- Johan Gilet (ORCID: https://orcid.org/0000-0002-2063-0638)
- Angélique Quartier (ORCID: https://orcid.org/0000-0002-2624-4869)
- Jérémie Courraud (ORCID: https://orcid.org/0000-0001-6339-1270)
- Jean-Louis Mandel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Universitaire de France (FR)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Institut National de Recherche en Santé Publique (ML)
- Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques (FR)
- Institut de Biologie Moléculaire et Cellulaire (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-03-13
- DOI
- https://doi.org/10.3389/fnins.2025.1533253
- Citations
- 5
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 9.39
Funders
- Fondation de France