Stereochemistry and Pharmacologic Action based on Plane Isomerism, Optical Isomerism and Conformational Isomerism

In a recent study, thalidomide has been proved to have positive pharmacological effects in the immune system, such as the treatment of lupus erythematosus and anti-tumor, but 60 years ago, because of its optical isomer, it led to many tragedies. This time, by collecting the data of papers, this paper mainly analyzes and summarizes the connection between stereochemistry and pharmacological action of drugs, and tried to find the main reasons for the isomers of different structures and their effects from the aspects of biology and medicine. 4-aminopyridine, 4-aminoquinoline, thalidomide, and macrolide compounds are mentioned in this article. It comes to the conclusion that the larger the plane structure area of some drugs, the better the efficacy; some drugs have therapeutic effects only in the R configuration and some drugs with different chiral structures have different pharmacological functions.