Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice
We conclude that Notch1 signalling may be a potentially useful therapeutic target in obesity, while aerobic exercise training suppresses the Notch1 pathway in the liver, contributing to the regulation of hepatic glucose and lipid metabolism in obese mice.
Authors
- Rafael Calais Gaspar (ORCID: https://orcid.org/0000-0002-2208-3527)
- Ivo Vieira de Sousa Neto (ORCID: https://orcid.org/0000-0002-1479-5866)
- Adelino Sánchez Ramos da Silva (ORCID: https://orcid.org/0000-0002-9679-8357)
- Utpal B. Pajvani (ORCID: https://orcid.org/0000-0001-5991-2723)
- José Rodrigo Pauli (ORCID: https://orcid.org/0000-0002-6129-1521)
- Júlio Sérgio Marchini (ORCID: https://orcid.org/0000-0001-9999-9149)
- Gabriela Ferreira Abud (ORCID: https://orcid.org/0000-0002-6301-3808)
- Luiz Guilherme Salvino da Silva (ORCID: https://orcid.org/0000-0002-5171-6573)
- Carla Barbosa Nonino (ORCID: https://orcid.org/0000-0001-8559-0772)
- Ana Paula Azevêdo Macêdo (ORCID: https://orcid.org/0000-0001-8188-4685)
- Vítor Rosetto Muñoz (ORCID: https://orcid.org/0000-0003-4280-6558)
- Isadora Carolina Betim Pavan
- Ellen Cristini de Freitas (ORCID: https://orcid.org/0000-0002-7343-2002)
- Fernando Moreira Simabuco (ORCID: https://orcid.org/0000-0002-1672-9686)
- Renan Fudoli Lins Vieira (ORCID: https://orcid.org/0000-0002-6525-7996)
- Susana Castelo Branco Ramos Nakandakari (ORCID: https://orcid.org/0000-0002-4451-2935)
- Dennys E. Cintra (ORCID: https://orcid.org/0000-0002-7954-5630)
- Eduardo Rochete Ropelle (ORCID: https://orcid.org/0000-0003-1655-9557)
- Wilson Salgado (ORCID: https://orcid.org/0000-0001-9796-0339)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Columbia University (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Liver International
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1111/liv.70068
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo