PADI4 facilitates stem‐like properties and cisplatin resistance through upregulating PRMT2/IDs family in oesophageal squamous cell carcinoma
The role of citrullinization in cisplatin resistance of OSCC. PADI4 citrullinate of PRMT2 and stabilize PRMT2. PADI4 citrullinate of PRMT2 promoting the transcription of IDs family (ID1, ID2 and ID3) via histone arginine methylation. PADI4 citrullinated PRMT2 affected the combination of PRMT2 and USP7. PADI4 citrullinate of PRMT2 at R312 site. PADI4 inhibitor GSK484 can affect the stemness of OSCC and cisplatin resistance.
Authors
- Anqi Feng
- Xiaoyuan Wang (ORCID: https://orcid.org/0000-0002-8199-0717)
- Shihan Zhang (ORCID: https://orcid.org/0000-0002-2377-5760)
- Yuan Chu (ORCID: https://orcid.org/0000-0001-6199-1598)
- Ziying Zhao
- Kang Fang (ORCID: https://orcid.org/0000-0002-8233-1182)
- Zhuyun Leng
- Mei‐Dong Xu (ORCID: https://orcid.org/0000-0002-7219-5826)
- Lingnan He (ORCID: https://orcid.org/0000-0002-0760-9789)
- Tao Chen (ORCID: https://orcid.org/0000-0001-8071-4959)
- Zhukai Chen
- Zehua Zhang
- Zeyu Wang (ORCID: https://orcid.org/0000-0001-6264-634X)
- Zhaoxing Li (ORCID: https://orcid.org/0009-0006-4621-2289)
- Hao Wu (ORCID: https://orcid.org/0000-0002-7767-9192)
Institutions
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70272
- Citations
- 6
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities