Access to 5- to 14-Membered <i>N</i>-Heterocycles by Alkylamination of 1,3-Dienes via Palladium Catalysis

Medium-sized rings show great potential in medicinal chemistry but are difficult to achieve via direct cyclization reaction. We herein report a versatile and mild photocatalytic approach for synthesis of medium- and large-sized vinyl <i>N</i>-heterocycles by radical-mediated cyclization of sulfonamides with pendant 1,3-dienes. The reaction involves the generation of radicals from alkyl halides and cyclization of π-allylpalladium species. This method could serve as a versatile platform for the construction of <i>N</i>-heterocycles with medium- and large-sized rings via Pd catalysis.