Combination of liquid‐ and solid‐phase extraction followed by achiral and chiral high‐performance liquid chromatography as an efficient and sensitive method for determination of panthenol in personal care products

The proposed extraction procedure is compatible with both the reversed-phase and normal-phase liquid chromatographic systems and is applicable in the analysis of a wide group of personal care products. The d-enantiomeric form (dexpanthenol) was detected in tested samples. The content of dexpanthenol in body milk, cream, and oil samples was found to be 0.2%-1.5%, 0.04%-0.7%, and 0.01%-0.03%, respectively.