Can circulating microRNAs predict colorectal cancer? Results from a nested case–control study of pre-diagnostic serum samples from two prospective biobanks
The study identified potential serum miRNA biomarkers associated with metastatic CRC, though statistical significance varied. These findings contribute to the understanding of miRNA profiles in pre-diagnostic CRC patients, emphasizing the need for further exploration of non-invasive biomarkers in large prospective studies.
Authors
- Eva Hofsli (ORCID: https://orcid.org/0000-0001-9856-4880)
- Robin Mjelle (ORCID: https://orcid.org/0000-0003-3509-4134)
- Eivind Ness‐Jensen (ORCID: https://orcid.org/0000-0001-6005-0729)
- Pål Sætrom (ORCID: https://orcid.org/0000-0001-8142-7441)
- Heljä‐Marja Surcel
Institutions
- Karolinska University Hospital (SE)
- Norwegian University of Science and Technology (NO)
- Oulu University Hospital (FI)
- Levanger Hospital (NO)
- Karolinska Institutet (SE)
- Borealis (Finland) (FI)
- St Olav's University Hospital (NO)
- University of Oulu (FI)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12885-025-13854-1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00