March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization
Our findings demonstrated that March2 is a novel endogenous defender that prevents AAD by inhibiting vascular smooth muscle cell apoptosis, suggesting that March2 represents a potential therapeutic target for AAD.
Authors
- Lin Wu (ORCID: https://orcid.org/0000-0001-6737-4646)
- Jun Ren (ORCID: https://orcid.org/0000-0002-0275-0783)
- Zheyun Li
- Rongjun Zou (ORCID: https://orcid.org/0000-0003-1981-5472)
- Yingmei Zhang
- Yuxin Du (ORCID: https://orcid.org/0000-0001-7429-3238)
- Yiran E. Li
- Lixin Wang (ORCID: https://orcid.org/0000-0002-1379-3906)
- Shengjun Xiong
- Tingfang Zhu
- Shuolin Liu
- Haoran Chen (ORCID: https://orcid.org/0000-0002-3594-6897)
- Qijun Zheng (ORCID: https://orcid.org/0000-0002-4525-8537)
- Yayu Wang
- Ling Lin (ORCID: https://orcid.org/0000-0002-6766-5432)
- Jie Lin (ORCID: https://orcid.org/0000-0003-3535-5250)
- Litao Wang (ORCID: https://orcid.org/0000-0002-7142-456X)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Fudan University (CN)
- National Health and Family Planning Commission (CN)
- LC Resources (United States) (US)
- Integrated Chinese Medicine (China) (HK)
- Zhongshan Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- L-3 Communications (United States) (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1161/circresaha.124.325049
- Citations
- 15
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 22.78