Biological Activity of Biomarkers Associated With Metastasis in Osteosarcoma Cell Lines
The gene functional enrichment analysis of DEGs enabled the identification of interaction networks in osteosarcoma, thereby revealing potential biomarkers. Moreover, the elucidated co-participation of TTX-sensitive Na<sub>V</sub>s and MMP-2 in facilitating migration and invasion suggests their suitability as novel prognostic biomarkers for osteosarcoma. Additionally, this study introduces a model delineating the potential interaction mechanism among ion channels, MMP-2, and other crucial factors in the metastatic cascade of osteosarcoma.
Authors
- Nidia Ednita Beltrán‐Hernández (ORCID: https://orcid.org/0000-0002-2363-5573)
- Leticia Vega‐Alvarado (ORCID: https://orcid.org/0000-0002-1200-1137)
- Luis Cárdenas (ORCID: https://orcid.org/0000-0002-6554-5832)
- Manuel Rivera (ORCID: https://orcid.org/0000-0001-9343-8383)
- Verónica Jiménez‐Jacinto (ORCID: https://orcid.org/0000-0001-6742-1537)
Institutions
- Universidad Autónoma del Estado de Morelos (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cam4.70391
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Consejo Nacional de Ciencia y Tecnología