Treat-And-Extend Versus Pro Re Nata Regimen of Intravitreal Conbercept Injection for Neovascular Age-Related Macular Degeneration: Results from COCOA, a Prospective, Open-Label, Multicenter, Randomized Phase IV Clinical Trial
Both 3+T&E and 3+PRN conbercept regimens effectively improved visual and anatomical outcomes in Chinese nAMD patients. The 3+T&E regimen was noninferior to 3+PRN in improving BCVA from baseline to week 48. The 3+T&E regimen enabled longer injection intervals while 3+PRN regimen with less injections is more cost-effective while maintaining a comparable safety profile. Treatment plan tailored to an individual patient's situation appears necessary.
Authors
- Liangbao An
- Bojie Hu (ORCID: https://orcid.org/0000-0001-7840-8290)
- Yuou Yao (ORCID: https://orcid.org/0000-0001-7213-1876)
- Ke Xiao (ORCID: https://orcid.org/0000-0002-6599-7118)
- Gang An (ORCID: https://orcid.org/0000-0003-4922-4614)
- Ke Fan (ORCID: https://orcid.org/0000-0003-3276-557X)
- Shaoping Ha
- Heng Miao
- Enzhong Jin (ORCID: https://orcid.org/0000-0003-1450-5846)
- Xun Deng
- Cheng Pei (ORCID: https://orcid.org/0000-0003-2805-728X)
- Rongping Dai (ORCID: https://orcid.org/0000-0002-7901-5998)
- Mingwei Zhao (ORCID: https://orcid.org/0000-0002-9458-1138)
- Jie Ma (ORCID: https://orcid.org/0000-0001-7386-5214)
- Baoguo Sun (ORCID: https://orcid.org/0000-0002-2758-2392)
- Jinfeng Qu (ORCID: https://orcid.org/0000-0001-6875-8393)
- Feng Wang (ORCID: https://orcid.org/0000-0001-7668-9674)
- Tonghe Zhang
- Huijun Qi
- Xionggao Huang (ORCID: https://orcid.org/0000-0002-9979-9750)
- Fang Wang (ORCID: https://orcid.org/0000-0001-8891-5878)
- Jingxiang Zhong (ORCID: https://orcid.org/0000-0002-5774-7602)
- Jun Li (ORCID: https://orcid.org/0000-0001-9121-6162)
- Jun Liu (ORCID: https://orcid.org/0000-0002-9001-9498)
- Jian Ye (ORCID: https://orcid.org/0000-0002-0909-4918)
- Tao Ye (ORCID: https://orcid.org/0000-0002-2780-9761)
- Weiqi Chen (ORCID: https://orcid.org/0000-0003-2852-8192)
- Xiaoxin Li (ORCID: https://orcid.org/0000-0002-4162-5918)
- Gongqiang Yuan (ORCID: https://orcid.org/0000-0003-0809-5502)
- Xiaoyan Peng (ORCID: https://orcid.org/0000-0002-4275-6856)
- Jing Hou (ORCID: https://orcid.org/0000-0003-1712-7502)
- Ming‐Jian Zhang (ORCID: https://orcid.org/0000-0002-6843-5911)
- Suqin Yu (ORCID: https://orcid.org/0000-0003-3043-4339)
- Hong Yin (ORCID: https://orcid.org/0000-0002-5045-7899)
- Bin Liu (ORCID: https://orcid.org/0000-0001-9882-876X)
- Xuan Shi (ORCID: https://orcid.org/0000-0002-6226-8833)
- Wenfang Zhang (ORCID: https://orcid.org/0000-0002-5478-9145)
- Jianhong Liang (ORCID: https://orcid.org/0000-0001-8695-2026)
- Tong Qian (ORCID: https://orcid.org/0000-0002-2393-125X)
- Xiyuan Zhou (ORCID: https://orcid.org/0000-0003-0858-5456)
- Xiaoqing Shi (ORCID: https://orcid.org/0009-0005-8604-7970)
- Yaoyao Sun
- Jie Zhang (ORCID: https://orcid.org/0000-0002-6802-9251)
- Guangming Wan
- Jia Jia Liu (ORCID: https://orcid.org/0000-0001-5548-8777)
- Lifei Wang
Institutions
- Beijing Tongren Hospital (CN)
- Academy of Medical Sciences (GB)
- Capital University (US)
- Army Medical University (CN)
- Chongqing University (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Shantou University (CN)
- Zhengzhou University (CN)
- Jinzhou Central Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Fourth People’s Hospital of Jinan (CN)
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Eye Center (SA)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Lanzhou University Second Hospital (CN)
- Peking University People's Hospital (CN)
- Wuxi No.2 People's Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shanxi Eye Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
- Hebei Eye Hospital (CN)
- Xian Yang Central Hospital (CN)
- Tianjin Medical University Eye Hospital (CN)
- Zhengzhou People's Hospital (CN)
- He Eye Hospital (CN)
- Henan Provincial Eye Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Shandong Eye Hospital (CN)
- Chinese People's Liberation Army (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
- Hangzhou Medical College (CN)
- Tianjin Medical University (CN)
- Lanzhou University (CN)
- Nanjing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Seminars in Ophthalmology
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1080/08820538.2025.2467853
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71