Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis
The present study identified tissue-specific candidate genes and validated high-confidence druggable targets for OA, providing new insights into the genetic landscape and biological processes involved in OA. Further functional studies are warranted to confirm these findings.
Authors
- Xiaolong Lin (ORCID: https://orcid.org/0000-0001-5414-5879)
- Yaojun Lu
- Jiapei Yao (ORCID: https://orcid.org/0009-0002-5807-1226)
- Jingjing Shang (ORCID: https://orcid.org/0000-0002-5267-933X)
- Xinjian Ye (ORCID: https://orcid.org/0000-0003-2300-6117)
- Xindie Zhou (ORCID: https://orcid.org/0000-0001-6194-6308)
- Yiping Weng
- Yong Huang (ORCID: https://orcid.org/0000-0003-1944-3656)
- Luming Nong
Institutions
- Stomatology Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1302/2046-3758.143.bjr-2024-0251.r1
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34