T cell receptor activation contributes to brain damage after intracerebral hemorrhage in mice
Our findings underscore the critical role of TCR activation in the mobilization and activation of brain-infiltrating T cells post-ICH. Inhibition of TCR activation via AX-024 administration might be developed as a promising therapeutic strategy to improve neurological outcomes following ICH. However, further research is necessary to thoroughly explore the complex pathophysiological processes involved.
Authors
- Yuwen Xiu (ORCID: https://orcid.org/0000-0002-2083-7129)
- Prasad V. G. Katakam (ORCID: https://orcid.org/0000-0002-4708-9140)
- Ning Liu (ORCID: https://orcid.org/0000-0002-5632-0359)
- Aaron S. Dumont (ORCID: https://orcid.org/0000-0002-8077-8992)
- Yinghua Jiang (ORCID: https://orcid.org/0000-0002-7344-7028)
- Mitchell D. Kilgore (ORCID: https://orcid.org/0000-0003-1101-6924)
- Yingjie Wang (ORCID: https://orcid.org/0000-0002-2646-0772)
- Xiaoying Wang (ORCID: https://orcid.org/0000-0001-5419-6318)
- Qiang Liu (ORCID: https://orcid.org/0000-0002-6621-0591)
- Fu‐Dong Shi (ORCID: https://orcid.org/0000-0002-9675-4637)
- Mengxuan Shi
- Di Zhou (ORCID: https://orcid.org/0000-0002-9766-860X)
- Wei-Na Jin
- Ningning Wang (ORCID: https://orcid.org/0009-0006-8874-4662)
- Thin Yadanar Sein
Institutions
- Tulane University (US)
- Capital Medical University (CN)
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s12974-025-03402-w
- Citations
- 5
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- Tulane University