<i>In vitro</i> and <i>in vivo</i> antibacterial activity, resistance analysis and molecular docking study of pleuromutilin derivatives against <i>Streptococcus suis</i>
A total of 68.66% of the 268 C14 side-chain modified pleuromutilin derivatives showed potent activity against S. suis. Among them, B49 showed good in vitro and in vivo antimicrobial effects against S. suis, indicating that B49 can be intensively studied as an antimicrobial candidate compound.
Authors
- Yixing Lu (ORCID: https://orcid.org/0009-0005-4740-850X)
- Changcheng Lin
- Zhenling Zeng
- Xinyue Luo
- You‐Zhi Tang (ORCID: https://orcid.org/0000-0003-2293-0287)
- Honghao Huang (ORCID: https://orcid.org/0000-0002-1939-2417)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-9893-8475)
- Peng Wan (ORCID: https://orcid.org/0000-0001-5193-3765)
- Wu S
Institutions
- South China Agricultural University (CN)
- Zhaoqing University (CN)
- Academy of Agricultural and Forestry Sciences (RO)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1093/jac/dkaf064
- Citations
- 2
- Primary Topic
- Veterinary medicine and infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.71