Prospects for Obtaining L-Methionine Using Biotechnological Methods Based on Escherichia coli and Corynebacterium glutamicum: Part 1. Application, Methods of L-Methionine Production, and Regulation of its Biosynthesis in Bacteria

Abstract—In the first part of the review presented, the role of L-methionine in the vital activity of various organisms and its application are considered. The main methods of obtaining it are presented briefly. The pathways of biosynthesis of L-methionine and its precursors, as well as their regulation in industrially significant bacterial species Escherichia coli and Corynebacterium glutamicum, are described. The current information on the uptake and assimilation reduction of sulfate and thiosulfate in these bacteria as the most important elements of metabolism limiting the possibility of oversynthesis of L-methionine is presented. At the same time, some approaches used in the creation of effective producer strains for the production of L-methionine using biotechnological methods are mentioned.