Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies
Our findings demonstrate the suitability of the ProPPr approach in FFPE brain tissue for unbiased discovery of local proteomes that provide valuable insights into the underlying proteomic landscape of tauopathies, shedding light on the molecular mechanisms underlying tau pathology. This first comprehensive characterization of tau-associated proteomes in a range of distinct tauopathies enhances our understanding of disease heterogeneity and mechanisms, informing strategies for the development of diagnostic biomarkers and targeted therapies.
Authors
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Dmytro Morderer (ORCID: https://orcid.org/0000-0003-3413-1597)
- Guojun Bu (ORCID: https://orcid.org/0000-0003-3491-1016)
- Naomi Kouri (ORCID: https://orcid.org/0000-0002-6841-9882)
- Feilin Liu (ORCID: https://orcid.org/0000-0002-3830-4355)
- Na Zhao (ORCID: https://orcid.org/0000-0001-8648-9422)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Anastasiia Maistrenko
- Michelle Salemi (ORCID: https://orcid.org/0000-0003-3990-7964)
- Melissa C. Wren (ORCID: https://orcid.org/0000-0001-9359-4941)
- Bilal Khalil (ORCID: https://orcid.org/0000-0001-7251-4340)
- Wilfried Rossoll (ORCID: https://orcid.org/0000-0002-9622-541X)
- Brett S. Phinney (ORCID: https://orcid.org/0000-0003-3870-3302)
- Nora Pobitzer
Institutions
- Hong Kong University of Science and Technology (HK)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
- University of California, Davis (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1186/s13024-025-00817-0
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- BrightFocus Foundation
- Chan Zuckerberg Initiative
- Tau Consortium