Pharmacodynamic assessment of apramycin against <i>Mycobacterium abscessus</i> in a hollow fibre infection model
Apramycin exhibited greater pharmacodynamic activity than amikacin against amikacin-susceptible M. abscessus isolates and may be a promising therapy for this pathogen. However, antibiotic combination strategies to minimize apramycin resistance from emerging may be necessary.
Authors
- Arunkumar Karunanidhi (ORCID: https://orcid.org/0000-0002-2480-8931)
- Arnold Louie (ORCID: https://orcid.org/0000-0001-6227-7580)
- Bikash Dangi
- Satoshi Mitarai (ORCID: https://orcid.org/0000-0002-2288-077X)
- Zackery P. Bulman (ORCID: https://orcid.org/0000-0002-5396-911X)
- Charles L. Daley (ORCID: https://orcid.org/0000-0003-3324-926X)
- Nidhi Singh (ORCID: https://orcid.org/0000-0002-3155-9427)
- Jeremy J. Johnson (ORCID: https://orcid.org/0000-0001-5489-2372)
- Brooke N Curry
- Sven N. Hobbie (ORCID: https://orcid.org/0000-0002-9205-0384)
Institutions
- University Hospital of Basel (CH)
- National Jewish Health (US)
- University of Florida (US)
- University of Illinois Chicago (US)
- Japan Anti Tuberculosis Association (JP)
- Institute for Learning Innovation (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1093/jac/dkaf073
- Citations
- 5
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Cystic Fibrosis Foundation