Multi‐Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals
Our analysis combining both genetic and nongenetic determinants highlighted that lifestyle factors and educational attainment can slightly reduce an individual's composite genetic risk for cardiovascular disease death.
Authors
- Yukihide Momozawa (ORCID: https://orcid.org/0000-0001-5638-3504)
- Yoshiki Tsuboi (ORCID: https://orcid.org/0000-0001-8145-3949)
- Hiroaki Ikezaki (ORCID: https://orcid.org/0000-0002-6677-6341)
- Kiyonori Kuriki (ORCID: https://orcid.org/0000-0003-4301-6566)
- Yuichiro Nishida (ORCID: https://orcid.org/0000-0003-2320-7234)
- Katsuyuki Miura (ORCID: https://orcid.org/0000-0002-2646-9582)
- Mako Nagayoshi (ORCID: https://orcid.org/0000-0002-1196-146X)
- Sadao Suzuki (ORCID: https://orcid.org/0000-0001-5988-4849)
- Kenji Wakai (ORCID: https://orcid.org/0000-0001-7388-7157)
- Shuntaro Sato (ORCID: https://orcid.org/0000-0002-6055-3649)
- Koji Suzuki (ORCID: https://orcid.org/0000-0002-3235-9558)
- Hidemi Ito (ORCID: https://orcid.org/0000-0002-8023-4581)
- Masahiro Nakatochi (ORCID: https://orcid.org/0000-0002-1838-4837)
- Nobuaki Michihata (ORCID: https://orcid.org/0000-0003-3091-114X)
- Sakurako Katsuura‐Kamano (ORCID: https://orcid.org/0000-0002-9582-674X)
- Teruhide Koyama (ORCID: https://orcid.org/0000-0002-8161-368X)
- Keitaro Tanaka (ORCID: https://orcid.org/0000-0002-5725-4736)
- Keitaro Matsuo (ORCID: https://orcid.org/0000-0003-1761-6314)
- Chihaya Koriyama (ORCID: https://orcid.org/0000-0003-3676-8866)
- Hiroto Narimatsu
- Shiroh Tanoue (ORCID: https://orcid.org/0000-0003-2625-2698)
- Ryosuke Fujii (ORCID: https://orcid.org/0000-0003-1730-2059)
- Asahi Hishida (ORCID: https://orcid.org/0000-0002-4867-0201)
- Naoyuki Takashima (ORCID: https://orcid.org/0000-0002-9593-6797)
- Yoshikuni Kita (ORCID: https://orcid.org/0000-0002-2366-1106)
- Yoko Kubo (ORCID: https://orcid.org/0009-0007-8390-0299)
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- Fujita Health University (JP)
- University of Shizuoka (JP)
- Shiga University of Medical Science (JP)
- Saga University (JP)
- Nagoya City University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Kyushu University Hospital (JP)
- Aichi Cancer Center (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Nagasaki University Hospital (JP)
- Nagoya University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1161/jaha.124.038572
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82