Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian Randomization
These findings suggest that gut microbiota composition and associated metabolites contribute to PAH development by regulating lung tissue gene expression. Our findings have implications for advancing gut microbiota-based PAH diagnostic technologies and targeted therapies.
Authors
- Lihuang Su (ORCID: https://orcid.org/0000-0001-5103-1817)
- Tongtong Pan (ORCID: https://orcid.org/0000-0003-4265-9623)
- Xiaoying Huang (ORCID: https://orcid.org/0000-0003-1102-3403)
- Dan Yao (ORCID: https://orcid.org/0000-0002-9629-6381)
- Yiying Zhang (ORCID: https://orcid.org/0000-0002-0366-0165)
- Ya Lin (ORCID: https://orcid.org/0000-0002-7613-3921)
- Xinghong Wang (ORCID: https://orcid.org/0000-0002-3662-8153)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-03-13
- DOI
- https://doi.org/10.1161/jaha.124.038150
- Citations
- 8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 7.49